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It is used in the Treatment of advanced gastric cancer or gastro-esophageal junction adenocarcinoma. Non-small cell Lung cancer. Metastatic Colorectal cancer.
Mechanism of action:
Cyramza (Ramicirumab) is a human monoclonal antibody (IgG1) against vascular endothelial growth factor receptor 2 (VEGFR2), a type II trans-membrane tyrosine kinase receptor expressed on endothelial cells. By binding to VEGFR2, Cyramza (Ramicirumab) prevents binding of its ligands (VEGF-A, VEGF-C, and VEGF-D), thereby preventing VEGF-stimulated receptor phosphorylation and downstream ligand-induced proliferation, permeability, and migration of human endothelial cells.
Dosage & Administration:
- As an infusion into a vein (intravenous, IV) every 2 weeks.
- There is no pill form of Cyramza (Ramicirumab).
- The amount of this medication you will receive depends on many other factors, including your weight and your general health or other health problems. Your doctor will determine your dosage and schedule.
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Diarrhea, headache, nausea, vomiting, mouth sores, or weakness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
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Or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Store: Cyramza (Ramicirumab) is handled and stored by a health care provider. You will not store it at home. Keep all medicines out of the reach of children and away from pets.
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Cyramza (Ramicirumab) is a human monoclonal antibody (IgG1) against vascular endothelial growth factor receptor 2 (VEGFR2), a type II trans-membrane tyrosine kinase receptor expressed on endothelial cells.
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